The gC and gE of duck plague virus (DPV) are encoded by the UL44 gene and the US8 gene respectively. They are the main components of the envelope and belong to multifunctional transmembrane proteins. gC is the main adsorption protein, which plays an important role in the process of viral adsorption and entry into host cells and its deletion can affect the virulence of the virus. Deletion of the ectodomain or intracellular domain of gE protein can significantly reduce the virulence of the virus. The research results of the gC/gE double gene deletion DPV strain show that the gC/gE double gene deletion strain is not pathogenic to ducks, and has the same level of protective efficacy compared with the commercial duck plague attenuated vaccine, and has a good prospect. The related research results were published online in Frontiers in Immunology on August 18, 2022 under the title "Evaluation of safety and immunogenicity of duck-plague virus gC/gE double gene deletion", doi: 10.3389/fimmu.2022.963009.