Full name: Mingshu Wang
Title/Position: Professor/Doctoral supervisor
Contact Address: Room 242, Building 6, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu City, Sichuan Province.
Email Address: mshwang@163.com
Education Background and Working Experience:
2002 to present, Sichuan Agricultural University, Professor
Research direction: Animal Microbiology and Immunology/Molecular Biology
Scientific research projects：
(1) National Key Technology Research and Development Program (18.33 million RMB)
Research and Application of Multivalent Vaccine for Important Diseases of Waterfowl (2017YFD0500800)
(2) National Natural Science Foundation of China (590,000 RMB)
Mechanism analysis of the effect of glycoprotein US7/US8 on life cycle and virulence of duck plague virus (32072894)
(3) National Natural Science Foundation of China (600,000 RMB)
Function of IE gene UL48 of duck plague virus and its effect on DPV life cycle (31872476)
(4) National Natural Science Foundation of China (820,000 RMB)
The function of major enzymes related to replication of duck hepatitis A virus (31472223)
(5) National Natural Science Foundation of China (820,000 RMB)
Mechanism of UL41 protein in duck plague virus regulating viral maturation and immune evasion (31272545)
(6) National Agricultural Science and Technology Achievements Transformation Fund (600,000 RMB)
National first-class new veterinary drug: the production process and industrialization demonstration of inactivated vaccine of duck infectious serositis (2013GB2F000412)
(7) Ministry of Agriculture Public Welfare Industry (Agriculture) Scientific Research Project (sub-project) (3.99 million RMB)
Rapid Diagnosis and Vaccine Development of Major Waterfowl Diseases (201003012)
Honorary awards:
More than 19 national and provincial science awards: including the second grade national award of technology invention and Second Prize of Scientific and Technological Progress(2013 and 2005), two first class prizes of technological invention of the Ministry of Education (2012 and 2015), two first class prizes of Sichuan Provincial Science and Technology Progress Award (2007 and 1995), one first class prize of China Industry University Research Cooperative Innovation Achievement Award [National Science Award Social Certificate No. 0191] (2016), one China Patent Excellence Award (2018), China Invention and Entrepreneurship Achievement Award [National Science award Social Certificate No. 0123], one first class prize (2018), six provincial/military science and technology progress second prizes (1996, 1996, 2001, 2005, 2016, 2017), one third class prize of provincial science and technology progress(2006).
Academic Achievements:
1. Main works:
Modern poultry disease diagnosis and prevention encyclopedia (800,000 words), Sichuan University press, 1997.
2. Representative articles
Published more than 300 SCI papers, representative papers are as follows
(1) Yaru Ning#, Yalin Huang#, Mingshu Wang#, Anchun Cheng*, Renyong Jia, Mafeng Liu, Dekang Zhu, Shun Chen, Xinxin Zhao, Shaqiu Zhang, Qiao Yang, Ying Wu, Juan Huang, Bin Tian, Xumin Ou, Sai Mao, Qun Gao, Di Sun, Yanlin Yu and Ling Zhang. Evaluation of the Safety and Immunogenicity of Duck-Plague Virus gE Mutants[J]. Front Immunol. April 2022,13:882796.
(2) Tianqiong He#, Mingshu Wang#, Anchun Cheng*, Qiao Yang, Ying Wu, Renyong Jia, Shun Chen, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Bin Tian, Xumin Ou, Sai Mao, Di Sun, Qun Gao, Yanling Yu, Ling Zhang and Yunya Liu. Duck plague virus UL41 protein inhibits RIG-I/MDA5-mediated duck IFN-β production via mRNA degradation activity[J]. Vet Res. 2022 Mar 18; 53:22.
(3) Xinhong Li, Xiaosi Tang, Mingshu Wang*, Anchun Cheng, Xumin Ou, Sai Mao, Di Sun, Qiao Yang, Ying Wu, Shaqiu Zhang, Dekang Zhu, Renyong Jia, Shun Chen, Mafeng Liu, Xinxin Zhao, Juan Huang, Qun Gao, Bin Tian, Yunya Liu, Yanling Yu, Ling Zhang, Leichang Pan. The lysine at position 151 of the duck hepatitis A virus 1 2C protein is critical for its NTPase activities[J]. Vet Microbiol. 2022 Jan;264:109300.
(4) Linjiang Yang#, Mingshu Wang#, Anchun Cheng*, Qiao Yang, Ying Wu, Juan Huang, Bin Tian, Renyong Jia, Mafeng Liu, Dekang Zhu, Shun Chen, Xinxin Zhao, Shaqiu Zhang, Xumin Ou, Sai Mao, Qun Gao, Di Sun, Yanlin Yu and Ling Zhang. UL11 Protein Is a Key Participant of the Duck Plague Virus in Its Life Cycle[J]. Front Microbiol. 2022 Jan 4;12:792361.
(5) Tong Zhou#, Dengjian Fan#, Mingshu Wang#, Anchun Cheng*, Ying Wu, Qiao Yang, Bin Tian, Renyong Jia, Xumin Ou, Sai Mao, Di Sun, Shaqiu Zhang, Dekang Zhu, Shun Chen, Mafeng Liu, Xinxin Zhao, Juan Huang, Qun Gao, Yanling Yu and Ling Zhang. Duck Plague Virus pUL48 Protein Activates the Immediate-Early Gene to Initiate the Transcription of the Virus Gene[J]. Front Microbiol. 2021 Dec 23;12:795730.
(6) Bingjie Shen, Yunjiao Li, Anchun Cheng, Mingshu Wang*, Ying Wu, Qiao Yang, Renyong Jia, Bin Tian, Xumin Ou, Sai Mao, Di Sun, Shaqiu Zhang, Dekang Zhu, Shun Chen, Mafeng Liu, Xin-Xin Zhao, Juan Huang, Qun Gao, Yunya Liu, Yanling Yu, Ling Zhang, and Leichang Pan. The LORF5 Gene Is Non-essential for Replication but Important for Duck Plague Virus Cell-to-Cell Spread Efficiently in Host Cells[J]. Front Microbiol. 2021 Dec 2;12:744408.
(7) Yalan Lai, Xiaoyan Xia, Anchun Cheng, Mingshu Wang*, Xumin Ou, Sai Mao, Di Sun, Shaqiu Zhang, Qiao Yang, Ying Wu, Dekang Zhu, Renyong Jia, Shun Chen, Mafeng Liu, Xin-Xin Zhao, Juan Huang, Qun Gao, Bin Tian, Yunya Liu, Yanling Yu, Ling Zhang and Leichang Pan. DHAV-1 Blocks the Signaling Pathway Upstream of Type I Interferon by Inhibiting the Interferon Regulatory Factor 7 Protein[J]. Front Microbiol. 2021 Nov 12;12:700434.
(8) Zezheng Liu, Qian Ye, Anchun Cheng, Xumin Ou, Sai Mao, Di Sun, Shaqiu Zhang, Xinxin Zhao, Qiao Yang, Ying Wu, Juan Huang, Qun Gao, Bin Tian and Mingshu Wang*. A viroporin-like 2B protein of duck hepatitis A virus 1 that induces incomplete autophagy in DEF cells[J]. Poult Sci. 2021 Oct;100(10):101331.
(9) Yuanzhi Liu, Anchun Cheng, Mingshu Wang*, Sai Mao, Xumin Ou, Qiao Yang, Ying Wu, Qun Gao, Mafeng Liu, Shaqiu Zhang, Juan Huang, Renyong Jia, Dekang Zhu, Shun Chen, Xinxin Zhao, Yanling Yu, Yunya Liu, Ling Zhang, Bin Tian, Leichang Pan. Duck Hepatitis A Virus Type 1 Induces eIF2α Phosphorylation-Dependent Cellular Translation Shutoff via PERK/GCN2[J]. Front Microbiol. 2021 Apr 12;12:624540.
(10) Sai Mao, Xumin Ou, Mingshu Wang*, Di Sun, Qiao Yang, Ying Wu, Renyong Jia, Dekang Zhu, Xinxin Zhao, Shun Chen, Mafeng Liu, Shaqiu Zhang, Juan Huang, Qun Gao, Yunya Liu, Yanling Yu, Ling Zhang, Bin Tian, Leichang Pan, Xiaoyue Chen, Anchun Cheng*. Duck hepatitis A virus 1 has lymphoid tissue tropism altering the organic immune responses of mature ducks [J]. Transbound Emerg Dis. 2021 Nov;68(6):3588-3600.
3. Main invention patent:
More than 60 national invention patents, and the representative patents are as follows:
(1) Mingshu Wang, Xingjian Wen, Anchun Cheng, Liping Wu, The construction method of type 3 duck hepatitis A virus mutation gene ISA-A117C-T1142A, National invention patent, No.201910551112, China, 2021
(2) Mingshu Wang, Liping Wu, Yuwei Zhang, Anchun Cheng, A pair of primer for the detection of UL48 gene of duck plague virus, as well as RT-PCR and fluorescence quantitative PCR detection method, National invention patent, No.201710856164, China, 2021
(3) Mingshu Wang, Tianqiong He, Anchun Cheng, The construction method of DPV CHv-ΔUL41 without trace deletion strain National invention patent, No.201811600145, China, 2021
(4) Mingshu Wang, Xingjian Wen, Anchun Cheng, The construction method of type 3 duck hepatitis A virus mutation gene ISA-C4334A, National invention patent, No.201910551576, China, 2021
(5) Mingshu Wang, Hao Qiu, Anchun Cheng, Application of Imp gene in Riemerella anatipestifer and its PCR detection method, National invention patent, No.ZL201510333169, China, 2021
(6) Mingshu Wang, Anchun Cheng, Qingzhu Li, Dekang Zhu, Mafeng Liu, Qiao Yao, The preparation method and application of truncated recombinant protein OmpA/MotB and its antibody in Riemerella anatipestifer, National invention patent, No.ZL201510359199, China, 2019
(7) Mingshu Wang, Qun Gao, Anchun Cheng, Qiao Yang, Xiaoyue Chen, The preparation method and application of truncated recombinant protein OmpH in Riemerella anatipestifer, National invention patent, No.ZL201510333169, China, 2018
(8) Mingshu Wang, Anchun Cheng, Yingying Cao, Qiao Yang, Xiaoyue Chen, The ELISA kit and preparation method of VP4 recombinant protein in type 1 duck hepatitis A virus, National invention patent, No.ZL201510736586, China, 2019
(9) Mingshu Wang, Anchun Cheng, Xiaoyue Chen, A lyophilizing method of duck hepatitis virus type 1, National invention patent, No.ZL201410397235, China, 2017
(10) Mingshu Wang, Anchun Cheng, Jie Huang, Renyong Jia, Qiao Yang, Kunfeng Sun, Shun Chen, Mafeng Liu, Dekang Zhu,Xiaoyue Chen, The preparation method and application of truncated recombinant protein UL7 of duck plague virus, National invention patent, No.ZL201410347473, China, 2016
