Full name: Shun Chen
Title/Position: Professor
Contact Address: College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
Email Address: shunchen@sicau.edu.cn
Education Background and Working Experience:
Education Background
2000-2004: Bachelor of Science, Sichuan Agricultural University, Chengdu, China
2004-2006: Master of Science, Sichuan Agricultural University, Chengdu, China
2006-2010: Doctor of Agriculture, Sichuan Agricultural University, Chengdu, China
2010-2011: Postdoctoral Fellows, School of Life Science and Technology, UESTC, Chengdu, China
2013-2014: Research Assistant, University of Maryland, College Park, Maryland, the USA
Working Experience
2011-2012: Assistant professor of College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
2012-2018: Associate professor of College of Veterinary Medicine, Sichuan Agricultural University
2019-present: Full Professor (permanent) College of Veterinary Medicine, Sichuan Agricultural University
2015–2020: Deputy Director of Preventive Veterinary Research Institute, College of Veterinary Medicine, Sichuan Agricultural University
2020-present: Deputy Dean of College of Veterinary Medicine, Sichuan Agricultural University
2020-present: Director of Preventive Veterinary Research Institute, Sichuan Agricultural University
Research Interest
1) The molecular mechanism of avian flavivirus proliferation, including the role of UTR and NSs in viral genome RNA replication and polyprotein processing.
2) The interplay between host antiviral response and avian flavivirus non-structure proteins.
3) The genome evolution on viral fitness following host shifts in avian flavivirus.
Personal profile
China is the country with the most breeding ducks in the world, with an annual output of about 4 billion ducks, accounting for more than 70% of the world's total. The number of ducks in Sichuan ranks among the top in China, and duck disease endangers social and economic development. Since 2004, my research has carried out basic theoretical and technical research on the strategic needs of Chinese social and economic development in Sichuan province, which achieved remarkable results. Main academic achievements include:
a. Duck infectious serositis inactivated vaccines：
1. The National Award for Technological Invention (the Second Award, 2013);
2. The National First Class New Veterinary Drug Certificate (2013);
3. The Ministry of Education Technology Invention Award (the first award, 2013);
b. Duck viral hepatitis attenuated live vaccine (CH60):
1. The National New Veterinary Drug Certificate (Second Class, 2013);
c. Research and application of comprehensive control system of duck viral hepatitis:
1. Second Prize of Sichuan Science and Technology Progress Award (2017);
d. A multi-platform in vitro operating system of duck flavivirus genome was established: Obtained four national invention patents.
e. Presided over 7 projects at or above the provincial and ministerial level including the National Natural Science Foundation of China. The research results were published in Pharmacology & Therapeutics, Journal of Virology, Journal of Immunology, etc. (the first or corresponding author). There are 81 articles in total, with a cumulative impact factor of over 200. Among them, there are 25 TOP journals of the Chinese Academy of Sciences with the highest impact factor of 10.557; the paper has been cited more than 480 times by Immunity, Nature Microbiology, Molecular Cell, PLOS Pathogens, eLife et al., of which the highest number of citations is 97.
Scientific research projects
2022-2024: Sichuan Provincial Department of Science and Technology International Scientific and Technological Innovation Cooperation (Shun PI)
2021-2023: China Central and Eastern European countries joint education project (Shun PI)
2020-2023: The Science Fund for Distinguished Young Scholars (Shun PI)
2016-2019: Foundation of the Ministry of Education of China for Returnees (Shun PI)
2017-2020: National Key Research and Development Program of China (Shun PI)
2018-2020: Sichuan-International joint research for science and technology (Shun PI)
2012-2014: Ph.D. Programs Foundation of Ministry of Education of China (Shun PI)
2012-2014: Sichuan Provincial Cultivation Program for Leaders of Disciplines in Science (Shun PI)
2013-2015: Key Fund Project of Sichuan Provincial Department of Education (Shun PI)
2014-2016: National Science and Technology Support Program (Shun PI)
Honorary awards
2012 The Ministry of Education Technology Invention Award (the first award), the fifth completed
2013 The National Award for Technological Invention (the Second Award), the fifth completed
2017 The Sichuan Technology Progress Award (the Second award), the seventh completed
2018 The Award of Fok Ying-Tong Education Foundation for Outstanding Young Teachers in the Higher Education Institutions of China
2018 The Top 100 Distinguished Young People in Sichuan
2019 The Ministry of Agriculture and Rural Affairs Excellent Innovation Team Award of Ministry
2019 The Ministry of Agriculture and Rural Affairs Science Popularization Award
2020 The Cheung Kong (Changjiang) Scholars Program of Ministry of Education of China Young Scholars
2021 The Sichuan Province youth talent support program
Representative articles
1) Wang T, Merits A, Wu Y, Wang M, Jia R, Zhu D, Liu M, Zhao X, Yang Q, Wu Y, Zhang S, Liu Y, Zhang L, Yu Y, Pan L, Chen S*, Cheng A*. 2020. cis-Acting Sequences and Secondary Structures in Untranslated Regions of Duck Tembusu Virus RNA Are Important for Cap-Independent Translation and Viral Proliferation. Journal of Virology 94. (16).
2) Wu Z, Zhang W, Wu Y, Wang T, Wu S, Wang M, Jia R, Zhu D, Liu M, Zhao X, Yang Q, Wu Y, Zhang S, Liu Y, Zhang L, Yu Y, Pan L, Merits A, Chen S*, Cheng A*. 2019. Binding of the Duck Tembusu Virus Protease to STING Is Mediated by NS2B and Is Crucial for STING Cleavage and for Impaired Induction of IFN-beta. Journal of Immunology 203:3374-3385.
3) Zhang W, Jiang B, Zeng M, Duan Y, Wu Z, Wu Y, Wang T, Wang M, Jia R, Zhu D, Liu M, Zhao X, Yang Q, Wu Y, Zhang S, Liu Y, Zhang L, Yu Y, Pan L, Chen S*, Cheng A*. 2020. Binding of Duck Tembusu Virus Nonstructural Protein 2A to Duck STING Disrupts Induction of Its Signal Transduction Cascade To Inhibit Beta Interferon Induction. Journal of Virology 94(9), e01850-19
4) Chen S*, Yang C, Zhang W, Mahalingam S, Wang M, Cheng A*. 2018. Flaviviridae virus nonstructural proteins 5 and 5A mediate viral immune evasion and are promising targets in drug development. Pharmacology & therapeutics 190:1-14.
5) Chen S, Zhang W, Wu Z, Zhang J, Wang M, Jia R, Zhu D, Liu M, Sun K, Yang Q, Wu Y, Chen X, Cheng A*. 2017. Goose Mx and OASL Play Vital Roles in the Antiviral Effects of Type I, II, and III Interferon against Newly Emerging Avian Flavivirus. Frontiers in immunology 8:1006.
6) Wu Z, Wu Y, Zhang W, Merits A, Simmonds P, Wang M, Jia R, Zhu D, Liu M, Zhao X, Yang Q, Wu Y, Zhang S, Huang J, Ou X, Mao S, Liu Y, Zhang L, Yu Y, Tian B, Pan L, Rehman MU, Chen S*, Cheng A*. 2020. The First Nonmammalian Pegivirus Demonstrates Efficient In Vitro Replication and High Lymphotropism. Journal of Virology 94:e01150-20.
7) Zhang W, Zeng M, Jiang B, Lu T, Guo J, Hu T, Wang M, Jia R, Zhu D, Liu M, Zhao X, Yang Q, Wu Y, Zhang S, Ou X, Liu Y, Zhang L, Yu Y, Pan L, Cheng A, Chen S*. 2021. Amelioration of Beta Interferon Inhibition by NS4B Contributes to Attenuating Tembusu Virus Virulence in Ducks. Frontiers in Immunology 12:671471.
8) Yu He, Xiaoli Wang, Jiaqi Guo, Li Mao, Senzhao Zhang, Tao Hu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Sai Mao, Xumin Ou, Qun Gao, Di Sun, Yunya Liu, Ling Zhang, Yanling Yu, Anchun Cheng*, Shun Chen*. 2021. Replication/Assembly Defective Avian Flavivirus With Internal Deletions in the Capsid Can Be Used as an Approach for Living Attenuated Vaccine. Frontiers in Immunology 12:694959.
9) He Y, Wang M, Chen S*, Cheng A. 2020. The role of capsid in the flaviviral life cycle and perspectives for vaccine development. Vaccine 38:6872-6881.
10) Chen S, Cheng A*, Wang M. 2013. Innate sensing of viruses by pattern recognition receptors in birds. Veterinary Research 44:82.
