Full name: Xumin Ou
Title/Position:
M.D., & Doctor of Agriculture, Principal Investigator
Contact Address:
Room 207, 6st Building, Sichuan Agricultural University-Chengdu campus
Email Address:
x.ou@sicau.edu.cn or oxumin@yahoo.com
Education Background and Working Experience:
2019- Sichuan Agricultural University Principal Investigator
2017-2021 Erasmus Medical Center Doctor of Medicine
2012-2019 Sichuan Agricultural University Doctor of Agriculture
2010-2012 Heilongjiang Bayi Agricultural University Bachelor of Agriculture
2008-2010 Heilongjiang University Bachelor of Engineering
Research direction:
tRNA biology, viral hepatitis and liver cancer
Personal profile:
At 2021, he successfully defensed at M.D. in Pathogen biology at Erasmus medical center (EMC). At 2019, he acquired a doctor degree of Agriculture at Sichuan Agricultural University (SICAU). Since 2019, he started to establish a research group at SICAU where he previously studied. His researches concentrated on viral hepatitis in animals and humans, as well as liver cancer. As the importance of tRNA in central dogma and modern life science, his research lines are not only well-integrated with biomedical research in both pathogen biology and cancer biology, but also tRNA biology. Now, his researches were funded by both scientific research project of Sichuan province (2020) and National Natural Science Foundation of China project (2021). Both concentrated on tRNA molecules. It is hoped that with our efforts in basic research of tRNA biology, we would create novel tRNA -based strategies to regulate mRNA translation and possibly apply this knowledge into clinical practices using tRNA-based therapy.
Scientific research projects：
l Mechanistically revealing the role of tRNA in regulating translation of Duck Hepatitis A virus in chicken embryo cells, 2022-2024, National Natural Science Foundation of China (Project No. 32102706), PI
l Mechanistical study of interferon α-mediated tRNAome change in translation disorder of antiviral gene, 2020-2022, Sichuan Provincial Department of Science and Technology (Project No.: 2020YJ0396), PI
Honorary awards:
l 2022, Department of Human Resources and Social Security of Sichuan Provincial, Talents of Sichuan Province Overseas High-level Overseas
l 2020, Frontier in Immunology, Reviewer
l 2020, Ministry of Education, Evaluation Expert of Graduate Dissertation
l 2018, Ministry of Education, National Scholarship for Doctoral Students
Academic Achievements:
1. Main works:
l 《Translational Decoding in Viral infection and Cancer Development》，2021，ISBN：978-94-6416-848-8
l 《A preliminary study on the attenuation mechanism of duck hepatitis virus and immune response in ducks》，2019，Doctor Thesis
2. Representative articles
l Ou, Xumin, Jingyu Cao, Anchun Cheng, Maikel P. Peppelenbosch, and Qiuwei Pan. "Errors in translational decoding: tRNA wobbling or misincorporation?." PLoS genetics 15, no. 3 (2019): e1008017.
l Zhang, Ruyi, Lisanne Noordam, Xumin Ou*, Buyun Ma, Yunlong Li, Pronay Das, Shaojun Shi et al. "The biological process of lysine‐tRNA charging is therapeutically targetable in liver cancer." Liver International 41, no. 1 (2021): 206-219.
l Xumin Ou, Buyun Ma, Ruyi Zhang, Zhijiang Miao, Anchun Cheng, Maikel P. Peppelenbosch, and Qiuwei Pan. "A simplified qPCR method revealing tRNAome remodeling upon infection by genotype 3 hepatitis E virus." FEBS letters 594, no. 12 (2020): 2005-2015.
l Xumin Ou, Wenjing Peng, Zhishuang Yang, Jingyu Cao, Mingshu Wang, Maikel P. Peppelenbosch, Qiuwei Pan, and Anchun Cheng. "Evolutionarily missing and conserved tRNA genes in human and avian." Infection, Genetics and Evolution 85 (2020): 104460.
l Xumin Ou, Zhishuang Yang, Dekang Zhu, Sai Mao, Mingshu Wang, Renyong Jia, Shun Chen et al. "Tracing genetic signatures of bat-to-human coronaviruses and early transmission of North American SARS-CoV-2." Transboundary and Emerging Diseases (2021).
l Xumin Ou, Mingshu Wang, Sai Mao, Jingyu Cao, Anchun Cheng, Dekang Zhu, Shun Chen et al. "Incompatible translation drives a convergent evolution and viral attenuation during the development of live attenuated vaccine." Frontiers in cellular and infection microbiology 8 (2018): 249.
l Mao, Sai, Xumin Ou, Mingshu Wang, Di Sun, Qiao Yang, Ying Wu, Renyong Jia et al. "Duck hepatitis A virus 1 has lymphoid tissue tropism altering the organic immune responses of mature ducks." Transboundary and Emerging Diseases 68, no. 6 (2021): 3588-3600.
l Miao, Zhijiang, Shaoshi Zhang, Xumin Ou, Shan Li, Zhongren Ma, Wenshi Wang, Maikel P. Peppelenbosch, Jiaye Liu, and Qiuwei Pan. "Estimating the global prevalence, disease progression, and clinical outcome of hepatitis delta virus infection." The Journal of infectious diseases 221, no. 10 (2020): 1677-1687.
l Ou, Xumin, Sai Mao, Jingyu Cao, Anchun Cheng, Mingshu Wang, Dekang Zhu, Shun Chen et al. "Comparative analysis of virus-host interactions caused by a virulent and an attenuated duck hepatitis A virus genotype 1." PloS one 12, no. 6 (2017): e0178993.
3. Main invention patent:
l An easy approach to detect mature tRNAome in human, Patent Reference #: ZL201811302188.X
