Introduction
Pasteurella multocida (P. multocida) is a Gram-negative coccobacillus belonging to the Pasteurellaceae family. It is a widespread opportunistic pathogen that infects human and a wide range of animal species. The disease manifests as fowl cholera in avian species, leading to significant economic losses in the poultry industry due to acute or peracute cases with signs of systemic disease. Nevertheless, P. multocida is still an enigmatic pathogen, and the exact molecular mechanisms responsible for pathogenesis in pasteurellosis remain largely unknown. We focus on functional analysis of lipopolysaccharide and global regulators that are closely associated with virulence, mechanisms of antibiotic resistance, vaccine development and genomics of P. multocida of avian origin.
Selected publications
[1] Zhao X, Yang F, Shen H, Liao Y, Zhu D, Wang M, Jia R, Chen S, Liu M, Yang Q, Wu Y, Zhang S, Huang J, Ou X, Mao S, Gao Q, Sun D, Tian B, Cheng A. Immunogenicity and protection of a Pasteurella multocida strain with a truncated lipopolysaccharide outer core in ducks. Vet Res. 2022, 53(1): 17.
[2] Zhao X, Shen H, Liang S, Zhu D, Wang M, Jia R, Chen S, Liu M, Yang Q, Wu Y, Zhang S, Huang J, Ou X, Mao S, Gao Q, Zhang L, Liu Y, Yu Y, Pan L, Cheng A. The lipopolysaccharide outer core transferase genes pcgD and hptE contribute differently to the virulence of Pasteurella multocida in ducks. Vet Res. 2021, 52(1): 37.
[3] Zhu D, Yuan D, Wang M, Jia R, Chen S, Liu M, Zhao X, Yang Q, Wu Y, Zhang S, Huang J, Liu Y, Zhang L, Yu Y, Pan L, Chen X, Cheng A. Emergence of a multidrug-resistant hypervirulent Pasteurella multocida ST342 strain with a floR-carrying plasmid. J Glob Antimicrob Resist. 2020, 20: 348-350.
[4] Zhu D, He J, Yang Z, Wang M, Jia R, Chen S, Liu M, Zhao X, Yang Q, Wu Y, Zhang S, Liu Y, Zhang L, Yu Y, You Y, Chen X, Cheng A. Comparative analysis reveals the Genomic Islands in Pasteurella multocida population genetics: on Symbiosis and adaptability. BMC Genomics. 2019, 20(1): 63.
[5] Zhao X, Liu Q, Xiao K, Hu Y, Liu X, Li Y, Kong Q. Identification of the crp gene in avian Pasteurella multocida and evaluation of the effects of crp deletion on its phenotype, virulence and immunogenicity. BMC Microbiol. 2016, 16(1): 125.
[6] Hua R, Zhao X, Cheng A. Research Progress in the Lipopolysaccharide of Pasteurella multocida. Acta Veterinaria Et Zootechnica Sinica, 2016, (10): 1961-1968.
Contact details
Dekang Zhu, Ph.D, Professor
Institute of Preventive Veterinary Medicine
Sichuan Agricultural University
No. 211, Huimin Road, Chengdu, Sichuan 611130, China
Email:
zdk24@sicau.edu.cn
Xinxin Zhao, Ph.D, Associate Professor
Institute of Preventive Veterinary Medicine
Sichuan Agricultural University
No. 211, Huimin Road, Chengdu, Sichuan 611130, China
Email:
xxinzhao@163.com
