Introduction
Salmonella enterica is a facultative anaerobic gram-negative bacterium with more than 2,600 serotypes and an important zoonotic pathogen worldwide. Salmonella infections cause enteric diarrheal disease or systemic invasive diseases in a broad spectrum of animal hosts and humans. Human consumption of Salmonella-contaminated products frequently led to salmonellosis outbreaks, posing a serious impact on public health. The global epidemiology of salmonellosis is complex, with diverse serovars, such as Typhimurium, Enteritidis, Newport, in different regions worldwide. Still, prophylactic vaccines with broad serovar coverage are unavailable.
Current research interests
1. Investigation of Salmonella prevalence in avian species
2. Identification of protective antigens in Salmonella enterica
3. Protective mechanism against Salmonella infection
4. Optimization of Salmonella-based vaccine delivery system
Selected publications
1. Guan, Y., Li, Y., Li, J., Yang, Z., Zhu, D., Jia, R., Liu, M., Wang, M., Chen, S., Yang, Q., Wu, Y., Zhang, S., Gao, Q., Ou, X., Mao, S., Huang, J., Sun, D., Tian, B., Cheng, A., Zhao, X.*, 2022. Phenotypic and genotypic characterization of antimicrobial resistance profiles in Salmonella isolated from waterfowl in 2002–2005 and 2018–2020 in Sichuan, China. Frontiers in Microbiology 13.
2. Zhao, X., Liang, S., Dai, Q., Jia, R., Zhu, D., Liu, M., Wang, M., Chen, S., Yang, Q., Wu, Y., Zhang, S., Zhang, L., Liu, Y., Yu, Y., Cheng, A.*, 2018. Regulated delayed attenuation enhances the immunogenicity and protection provided by recombinant Salmonella enterica serovar Typhimurium vaccines expressing serovar Choleraesuis O-polysaccharides. Vaccine 36, 5010-5019.
3. Zhao, X., Dai, Q., Jia, R., Zhu, D., Liu, M., Wang, M., Chen, S., Sun, K., Yang, Q., Wu, Y., Cheng, A.*, 2017. Two Novel Salmonella Bivalent Vaccines Confer Dual Protection against Two Salmonella Serovars in Mice. Front Cell Infect Microbiol 7, 391.
4. Tang, T., Gao, Q., Barrow, P., Wang, M., Cheng, A.*, Jia, R., Zhu, D., Chen, S., Liu, M., Sun, K., Yang, Q., Chen, X., 2015. Development and evaluation of live attenuated Salmonella vaccines in newly hatched duckings. Vaccine 33, 5564-5571.
5. Yu, X., Jia, R., Huang, J., Shu, B., Zhu, D., Liu, Q., Gao, X., Lin, M., Yin, Z., Wang, M., Chen, S., Wang, Y., Chen, X., Cheng, A.*, 2012. Attenuated Salmonella typhimurium delivering DNA vaccine encoding duck enteritis virus UL24 induced systemic and mucosal immune responses and conferred good protection against challenge. Vet Res 43, 56.
Selected invention Patents
Xinxin Zhao, Anchun Cheng, Qinlong Dai. Construction method and application of recombinant Salmonella Typhimurium bivalent vaccine strain. Chinese Patent: ZL201710732719.8, July 07, 2021.
Contact details
Xinxin Zhao, Ph.D, Associate Professor
Institute of Preventive Veterinary Medicine
Sichuan Agricultural University
No. 211, Huimin Road, Chengdu, Sichuan 611130, China
Email:
xxinzhao@163.com
