Duck Enteritis virus-Institute of Preventive Veterinary Medicine, Sichuan Agricultural University

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Duck Enteritis virus

Introduction

Duck enteritis virus (DVE), also called duck plague virus (DPV), a member of the alphaherpesvirus subfamily, which can cause severe damage and lifelong latent infection in ducks, geese and swans. It is worldwide distribution, wherein migratory waterfowl plays a crucial role in its transmission within and between continents. The morbidity and mortality of DEV infected young ducklings or unprotected ducks reaches up to 100%, resulting in considerable economic losses to the commercial duck industry and poses a continuous threat to wild and migratory waterfowl populations.

Recent researches have revealed the viral genome structure and multiple functions of many DEV genes, but less is known about the underlying mechanisms of viral replication，pathogenesis, establish and reactivation of latency. Based on this, our research topics are as follows:

1. The proteins involved in DEV replication and underlying molecular mechanism.

2. Interactions between viral and host proteins and details of mechanisms involved in gene regulation.

3. The pathogenesis investigation including autophagy, apoptosis, immune response and infection patterns caused by DEV.

4. Cell model establishment for DEV.

5. The development of DEV vectored vaccines for preventing multiple diseases of waterfowl.

6. The development of high-throughput, sensitive and rapid diagnostic methods and reagents for DEV detection.

Selected Publications

1. Yu You, Tian Liu, Mingshu Wang, Anchun Cheng*, Renyong Jia, Qiao Yang, Ying Wu, Dekang Zhu, Shun Chen, Mafeng Liu, XinXin Zhao, Shaqiu Zhang, Yunya Liu, Yanling Yu & Ling Zhang. The suppression of apoptosis by α-herpesvirus [J]. Cell Death & Disease, 2017, 8(4):e2749.

2. Ying Wu, Anchun Cheng*, Mingshu Wang, Dekang Zhu,Renyong Jia, Shun Chen, Yi Zhou, Xiaoyue Chen. Comparative genomic analysis of duck enteritis virus strains [J]. Journal of Virology, 2012, 86(24):13841-13842.

3. Ying Wu, Anchun Cheng*, Mingshu Wang, Qiao Yang, Dekang Zhu, Renyong Jia, Shun Chen, Yi Zhou, Xiaoyue Chen. Complete Genomic Sequence of Chinese Virulent Duck Enteritis Virus [J]. Journal of Virology, 2012, 86(10):5965.

4. Tianqiong He, Mingshu Wang, Anchun Cheng*, Qiao Yang, Ying Wu, Renyong Jia, Shun Chen, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Bin Tian, Xumin Ou, Sai Mao, Di Sun, Qun Gao, Yanling Yu, Ling Zhang and Yunya Liu. Duck plague virus UL41 protein inhibits RIG‑I/MDA5‑mediated duck IFN‑β production via mRNA degradation activity[J]. Veterinary Research, 2022, 53:22, doi: org/10.1186/s13567-022-01043-y.

5. Yaru Ning, Yalin Huang, Mingshu Wang, Anchun Cheng*, Renyong Jia, Mafeng Liu, Dekang Zhu, Shun Chen, Xinxin Zhao, Shaqiu Zhang, Qiao Yang, Ying Wu, Juan Huang, Bin Tian, Xumin Ou, Sai Mao, Qun Gao, Di Sun, Yanlin Yu and Ling Zhang. Evaluation of the Safety and Immunogenicity of Duck-Plague Virus gE Mutants[J]. Frontiers in Immunology, April 2022,13:882796, doi: 10.3389/fimmu.2022.882796.

6. Tong Zhou, Dengjian Fan, Mingshu Wang, Anchun Cheng*, Ying Wu, Qiao Yang, Bin Tian, Renyong Jia, Xumin Ou, Sai Mao, Di Sun, Shaqiu Zhang, Dekang Zhu, Shun Chen, Mafeng Liu, Xinxin Zhao, Juan Huang, Qun Gao, Yanling Yu and Ling Zhang. Duck Plague Virus pUL48 Protein Activates the Immediate-Early Gene to Initiate the Transcription of the Virus Gene[J]. Frontiers in Microbiology, December 2021, Volume 12, Article 795730, doi: 10.3389/fmicb.2021.795730.

7. Bingjie Shen, Yunjiao Li, Anchun Cheng, Mingshu Wang*, Ying Wu, Qiao Yang, Renyong Jia, Bin Tian, Xumin Ou, Sai Mao, Di Sun, Shaqiu Zhang, Dekang Zhu, Shun Chen, Mafeng Liu, Xin-Xin Zhao, Juan Huang, Qun Gao, Yunya Liu, Yanling Yu, Ling Zhang, and Leichang Pan. The LORF5 Gene Is Non-essential for Replication but Important for Duck Plague Virus Cell-to-Cell Spread Efficiently in Host Cells[J]. Frontiers in Microbiology, December 2021, Volume 12, Article 744408, doi: 10.3389/fmicb.2021.744408.

8. Linjiang Yang, Bingjie Shen, Mingshu Wang, Anchun Cheng*, Qiao Yang, Ying Wu, Juan Huang, Bin Tian, Renyong Jia, Mafeng Liu, Dekang Zhu, Shun Chen, Xinxin Zhao, Shaqiu Zhang, Xumin Ou, Sai Mao, Qun Gao, Di Sun. The intracellular domain of duck plague virus glycoprotein E affects UL11 protein incorporation into viral particles[J]. Veterinary Microbiology, 257 (2021) 109078, doi: org/10.1016/j.vetmic.2021.109078.

9. Ying Wu*†, Qiqi Yang, Mingshu Wang, Shun Chen, Renyong Jia,Qiao Yang, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang,Juan Huang, Xumin Ou, Sai Mao, Qun Gao, Di Sun, Bin Tian and Anchun Cheng*. Multifaceted Roles of ICP22/ORF63 Proteins in the Life Cycle of Human Herpesviruses[J].Frontiers in Micrrobiology 2021,12:668461.

10. He Q†, Wu Y*†, Wang M, Chen S, Jia R, Yang Q, Zhu D, Liu M, Zhao X, Zhang S, Huang J, Ou X, Mao S, Gao Q, Sun D, Tian B, Cheng A. ICP22/IE63 Mediated Transcriptional Regulation and Immune Evasion: Two Important Survival Strategies for Alphaherpesviruses. Front Immunol. 2021 Dec 2;12:743466.

11. Tian Liu, Anchun Cheng*, Mingshu Wang, Renyong Jia, Qiao Yang, Ying Wu, Kunfeng Sun, Dekang Zhu, Shun Chen, Mafeng Liu, XinXin Zhao and Xiaoyue Chen. RNA-seq comparative analysis of Peking ducks spleen gene expression 24 h post-infected with duck plague virulent or attenuated virus [J]. Veterinary Research, 2017, 48(1):47.

12. Yang L, Yang Q, Wang M, Jia R, Chen S, Zhu D, Liu M, Wu Y, Zhao X, Zhang S, Liu Y, Yu Y, Zhang L, Chen X, Cheng A, Terminase Large Subunit Provides a New Drug Target for Herpesvirus Treatment. Viruses. 2019, 11(3).

13. Peilin Ruan, Xin Feng, Anchun Cheng, Mingshu Wang*, Wei Zhang, Ying Wu, Qiao Yang, Bin Tian, Xuming Ou, Di Sun, Shaqiu Zhang, Sai Mao, Dekang Zhu, Renyong Jia, Shun Chen, Mafeng Liu, Xinxin Zhao, Juan Huang, Qun Gao, Yanling Yu, Ling Zhang and Leichang Pan. Evaluation of safety and immunogenicity of duck-plague virus gC/gE double gene deletion[J]. Frontiers in Immunology, 18th Aug 2022, 13:963009, doi: 10.3389/fimmu.2022.963009.

14. Yaru Ning, Yalin Huang, Mingshu Wang, Anchun Cheng*, Qiao Yang, Ying Wu, Bin Tian, Xumin Ou, Juan Huang, Sai Mao, Di Sun, Xinxin Zhao, Shaqiu Zhang, Qun Gao, Shun Chen, Mafeng Liu, Dekang Zhu, and Renyong Jia. Alphaherpesvirus Glycoprotein E: A Review of Its Interactions with Other Proteins of the Virus and Its Application in Vaccinology[J]. Frontiers In Microbiology,13, doi:org/10.3389/fmicb.2022.970545.

15. Tian B, Cai D, Wang M, He T, Deng L, Wu L, Jia R, Zhu D, Liu M, Chen S, Yang Q, Wu Y, Zhao X, Zhang S, Rehman MU, Huang J, Ou X, Mao S, Gao Q, Wen X, Sun D, Yu Y, Zhang L, Liu Y, Pan L, Chen X, Cheng A. SC75741 antagonizes vesicular stomatitis virus, duck Tembusu virus, and duck plague virus infection in duck cells through promoting innate immune responses. Poult Sci. 2021, 100(5): 101085.

16. Tian B, Cai D, He T, Deng L, Wu L, Wang M, Jia R, Zhu D, Liu M, Yang Q, Wu Y, Zhao X, Chen S, Zhang S, Huang J, Ou X, Mao S, Yu Y, Zhang L, Liu Y, Cheng A. Isolation and Selection of Duck Primary Cells as Pathogenic and Innate Immunologic Cell Models for Duck Plague Virus. Front Immunol. 2019, 10: 3131.

17. Wu L, Tian B, Wang M, Cheng A, Jia R, Zhu D, Liu M, Yang Q, Wu Y, Huang J, Zhao X, Chen S, Zhang S, Ou X, Mao S, Gao Q, Sun D, Yu Y, Zhang L, Pan L. Duck Plague Virus Negatively Regulates IFN Signaling to Promote Virus Proliferation via JNK Signaling Pathway. Front Immunol. 2022, 13: 935454.

18. Jieyu Wan, Fangjie Li, Mingshu Wang*, Anchun Cheng, Bin Tian, Qiao Yan, Ying Wu, Xumin Ou, Sai Mao, Di Sun, haqiu Zhang, Juan Huang, Qun Gao, XinXin Zhao, Shun Chen, Mafeng Liu, Renyong Jia and Dekang Zhu. The protein encoded by the duck plague virus UL14 gene regulates virion morphogenesis and affects viral replication[J]. Poultry Science, 2022, 101:101863, doi：org/10.1016/j.psj.2022.101863.

19. Linjiang Yang, Mingshu Wang, Anchun Cheng*, Qiao Yang, Ying Wu, Juan Huang, Bin Tian, Renyong Jia1, Mafeng Liu, Dekang Zhu, Shun Chen, Xinxin Zhao, Shaqiu Zhang, Xumin Ou, Sai Mao, Qun Gao and Di Sun. Features and functions of the conserved herpesvirus tegument protein pUL11 and its binding partners[J]. Frontiers in Microbiology, 03 June, 2022, 13:829754, doi: org/10.3389/fmicb.2022.829754.

20. Linjiang Yang, Xixia Hu, Anchun Cheng, Mingshu Wang, Renyong Jia, Qiao Yang, Ying Wu, Shun Chen, Mafeng Liu, Dekang Zhu, Xumin Ou, XingJian Wen, Sai Mao, Di Sun, Shaqiu Zhang, Xinxin Zhao, Juan Huang, Qun Gao, Yunya Liu, Yanling Yu, Ling Zhang, Bin Tian, Leichang Pan, Xiaoyue Chen. Two nuclear localization signals regulate intracellular localization of the duck enteritis virus UL13 protein[J]. Poultry Science, 2021 Jan, 100(1):26-38, doi: 10.1016/j.psj.2020.09.069.

Invention Patents:

1. Cheng Anchun, Liu Tian, Wang Mingshu. Duck Plague Virus gE-gI Double Gene Markerless Deletion Strain DPV CHv-ΔgE+ΔgI and Construction Method Thereof. Holland Patent NO. 2025748. Filed on: 2021.4.21.

2. Wang Mingshu, He Tianqiong, Cheng Anchun. A duck plague virus UL41 gene markerlessdeletion strain CHv-BAC-G-ΔUL41 and a construction method thereof. Australia Patent NO. 2021100508. Filed on：2021.03.21.

3. Cheng Anchun, Liu Tian, Wang Mingshu. DPV CHv-ΔgI of gI gene-free strain of duck plague virus and its construction method. Australia Patent NO. 2020101881. Filed on：2020.09.09.

4. Cheng Anchun, Liu Tian, Wang Mingshu. DPV CHv-gI gene-free strain of duck plague virus and its construction method. Australia Patent NO.2020101881. Filed on：2020.09.09.

5. Wu Ying; Li Yangguang; Cheng Anchun; Wang Mingshu; Construction of the duck plague virus US1 gene deletion mutant based on scarless recombination system. Chinese Patent NO. 201811600069.2. Filed on: 2018.12.26.

6. Qiao Yang, Anchun Cheng, Mingshu Wang, Kunfeng Sun, Renyong Jia, Dekang Zhu, Shun Chen, Mafeng Liu. The preparation method and applications of duck plague virus UL15 exon I recombinant protein. Chinese Patent Application No.: 201410520084.1. Filed on: 2017.10.31.

7. Mingshu Wang, Anchun Cheng, Jie Huang, Renyong Jia, Qiao Yang, Kunfeng Sun, Shun Chen, Mafeng Liu, Dekang Zhu, Xiaoyue Chen. The preparation method and applications of anatid herpesvirus 1 truncated UL7 recombinant protein. Chinese Patent Application No.: 201410347473.9. Filed on: 2016.6.8.

8. Mingshu Wang, Xixia Hu, Anchun Cheng, Xiaoyue Chen, Renyong Jia. The preparation and applications of truncated recombinant duck enteritis virus UL13 protein and its polyclonal antibody. Chinese Patent No.: 201310557397.X. Filed on: 2015.5.20.

9. Anchun Cheng, Kunfeng Sun, Hua Chang, Mingshu Wang, Xiaoyue Chen. Construction of duck enteritis virus transfer vector pUC-ΔgE-EGFP and the recombinant strain DPV-ΔgC-EGFP. Chinese Patent No.: 201210139063.6. Filed on: 2014.12.3.

10. Anchun Cheng, Kunfeng Sun, Mingshu Wang, Xiaoyue Chen. Construction of duck enteritis virus transfer vector pUC-ΔgC-EGFP and the gC knockout strain DPV-ΔgC-EGFP. Chinese Patent No.: 201210139064.0. Filed on: 2014.9.24.

11. Anchun Cheng, Ying Wu, Mingshu Wang, Xiaoyue Chen. The preparation of recombinant prokaryotic expressed DEV UL55 protein for detecting duck enteritis virus antibody. Patent No.: 201110047060.5.Filed on:2014.8.6.

12. Anchun Cheng, Ying Wu, Mingshu Wang, Xiaoyue Chen. Development of duck enteritis virus antibody detection method based on recombinant DEV UL55 protein. Patent No.: 201110047062.4. Filed on: 2014.3.19.

13. Qin He, Anchun Cheng, Mingshu Wang, Xiaoyue Chen. The development of an ELISA kit and application for detecting duck plague virus antibody (UL16). Chinese Patent Application No.: 201110105302.1. Filed on: 2014.01.01.

14. Anchun Cheng, Xiaoyuan Yang, Mingshu Wang, Xiaoyue Chen. The development and application of a kit based on duck plague virus truncated gG recombination protein. Chinese Patent Application No.: 201110177133.2. Filed on: 2013.9.25.

15. Anchun Cheng, Mingshu Wang, Chanjuan Shen, Xiaoyue Chen. Preparation method and application for colloidal gold immunochromatographic strip based on UL51 recombinant protein. Chinese Patent Application No.: 201010299530.2. Filed on: 2013.9.25.

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